Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor.

ABSTRACT: Although protein receptors on the plasma membrane involved in the initial steps of productive HIV-1 infection have been well characterized, little is known about interactions between cellular carbohydrate receptors and HIV-1. Here, we report the involvement of a carbohydrate receptor, the macrophage mannose receptor (MR), and its role in supporting HIV-1 binding and entry. HIV-1 can enter the cytoplasm of human macrophages and microglia as well as murine macrophages by MR, although no subsequent viral replication was observed. Correspondingly, HIV-1 entry into Cos-7 cells after induction of expression of MR by transfection with MR-cDNA did not demonstrate viral replication. Our studies suggest that whereas MR may serve as a binding and an entry site, the MR-mediated pathway does not lead t

SUBMITTER: Trujillo JR 

PROVIDER: S-EPMC1821124 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature