Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle Proteomes.

ABSTRACT: Complete and accurate profiling of cellular organelle proteomes, while challenging, is important for the understanding of detailed cellular processes at the organelle level. Mass spectrometry technologies coupled with bioinformatics analysis provide an effective approach for protein identification and functional interpretation of organelle proteomes. In this study, we have compiled human organelle reference datasets from large-scale proteomic studies and protein databases for 7 lysosome-related organelles (LROs), as well as the endoplasmic reticulum and mitochondria, for comparative organelle proteome analysis. Heterogeneous sources of human organelle proteins and rodent homologs are mapped to human UniProtKB protein entries based on ID and/or peptide mappings, followed by functional annot

SUBMITTER: Hu ZZ 

PROVIDER: S-EPMC1828028 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature