Evaluation of the structural quality of modeled proteins by using globularity criteria.

ABSTRACT:

Background

The knowledge of the three-dimensional structure of globular proteins is fundamental for a detailed investigation of their functional properties. Experimental methods are too slow for structure investigation on a large scale, while computational prediction methods offer alternatives that are continuously being improved. The international Comparative Assessment of Structure Prediction (CASP), an "a posteriori" evaluation of the quality of theoretical models when the experimental structure becomes available, demonstrates that predictions can be successful as well as unsuccessful, and this suggests the necessity for evaluations able to discard "a priori" the wrong models.

Results

We analyzed different structural properties of globular proteins for experimentally solv

SUBMITTER: Costantini S 

PROVIDER: S-EPMC1828058 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature