The more the merrier: comparative analysis of microarray studies on cell cycle-regulated genes in fission yeast.

ABSTRACT: The last two years have seen the publication of three genome-wide gene expression studies of the fission yeast cell cycle. While these microarray papers largely agree on the main patterns of cell cycle-regulated transcription and its control, there are discrepancies with regard to the identity and numbers of periodically expressed genes. We present benchmark and reproducibility analyses showing that the main discrepancies do not reflect differences in the data themselves (microarray or synchronization methods seem to lead only to minor biases) but rather in the interpretation of the data. Our reanalysis of the three datasets reveals that combining all independent information leads to an improved identification of periodically expressed genes. These evaluations suggest that the available mi

SUBMITTER: Marguerat S 

PROVIDER: S-EPMC1828074 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature