H2A.Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state.

ABSTRACT: Many genes are recruited to the nuclear periphery upon transcriptional activation. The mechanism and functional significance of this recruitment is unclear. We find that recruitment of the yeast INO1 and GAL1 genes to the nuclear periphery is rapid and independent of transcription. Surprisingly, these genes remain at the periphery for generations after they are repressed. Localization at the nuclear periphery serves as a form of memory of recent transcriptional activation, promoting reactivation. Previously expressed GAL1 at the nuclear periphery is activated much more rapidly than long-term repressed GAL1 in the nucleoplasm, even after six generations of repression. Localization of INO1 at the nuclear periphery is necessary and sufficient to promote more rapid activation. This form of tra

SUBMITTER: Brickner DG 

PROVIDER: S-EPMC1828143 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature