Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells.

ABSTRACT: Cyclin protein behavior has not been systematically investigated in multinucleated cells with asynchronous mitoses. Cyclins are canonical oscillating cell cycle proteins, but it is unclear how fluctuating protein gradients can be established in multinucleated cells where nuclei in different stages of the division cycle share the cytoplasm. Previous work in A. gossypii, a filamentous fungus in which nuclei divide asynchronously in a common cytoplasm, demonstrated that one G1 and one B-type cyclin do not fluctuate in abundance across the division cycle. We have undertaken a comprehensive analysis of all G1 and B-type cyclins in A. gossypii to determine whether any of the cyclins show periodic abundance across the cell cycle and to examine whether cyclins exhibit functional redundancy in such

SUBMITTER: Hungerbuehler AK 

PROVIDER: S-EPMC1828934 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature