Age-related urinary excretion of BK polyomavirus by nonimmunocompromised individuals.

ABSTRACT: Two polyomaviruses, BK virus (BKV) and JC virus (JCV), are ubiquitous in the human population, generally infecting children asymptomatically and then persisting in renal tissue. It is generally thought that reactivation leads to productive infection for both viruses, with progeny shed in the urine. Several studies have shown that the rate of JC viruria increases with the age of the host, but a systematic approach to examine the shedding of BKV has not been developed. To elucidate the relationship between BK viruria and host age, we obtained urine from donors (healthy volunteers or nonimmunocompromised patients) who were divided into nine age groups, each containing 50 members. A high-sensitivity PCR was used to detect BKV and JCV DNA from urinary samples, and the specificity of amplificati

SUBMITTER: Zhong S 

PROVIDER: S-EPMC1828952 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature