Evidence for a link between parasite genotype and outcome of infection with Entamoeba histolytica.

ABSTRACT: The factors determining whether a person infected with Entamoeba histolytica develops disease remain obscure. To investigate whether the parasite genome contributes to the outcome, we have investigated the distribution of parasite genotypes among E. histolytica-infected individuals in Bangladesh. Samples were obtained from individuals who either were asymptomatic, had diarrhea/dysentery, or had developed a liver abscess. Genotypes were determined by using six tRNA-linked polymorphic markers, and their distributions among the three sample groups were evaluated. A significant population differentiation in the genotype distribution was found for four of the six individual markers as well as for the combined genotypes, suggesting that the parasite genome does contribute in some way to the outc

SUBMITTER: Ali IK 

PROVIDER: S-EPMC1829016 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature