Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant Acinetobacter baumannii.

ABSTRACT: In the last few years, phenotypically carbapenem resistant Acinetobacter strains have been identified throughout the world, including in many of the hospitals and intensive care units (ICUs) of Australia. Genotyping of Australian ICU outbreak-associated isolates by pulsed-field gel electrophoresis of whole genomic DNA indicated that different strains were cocirculating within one hospital. The carbapenem-resistant phenotype of these and other Australian isolates was found to be due to carbapenem-hydrolyzing activity associated with the presence of the blaOXA-23 gene. In all resistant strains examined, the blaOXA-23 gene was adjacent to the insertion sequence ISAba1 in a structure that has been found in Acinetobacter baumannii strains of a similar phenotype from around the world; blaOXA-51-

SUBMITTER: Valenzuela JK 

PROVIDER: S-EPMC1829019 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature