Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family.

ABSTRACT: To establish a vacuole that supports bacterial replication, Legionella pneumophila translocates a large number of bacterial proteins into host cells via the Dot/Icm type IV secretion system. Functions of most of these translocated proteins are unknown, but recent investigations suggest their roles in modulating diverse host processes such as vesicle trafficking, autophagy, ubiquitination, and apoptosis. Cells infected by L. pneumophila exhibited resistance to apoptotic stimuli, but the bacterial protein directly involved in this process remained elusive. We show here that SidF, one substrate of the Dot/Icm transporter, is involved in the inhibition of infected cells from undergoing apoptosis to allow maximal bacterial multiplication. Permissive macrophages harboring a replicating sidF muta

SUBMITTER: Banga S 

PROVIDER: S-EPMC1829273 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature