Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study.

ABSTRACT:

Background

The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes.

Participants and methods

To investigate the association between LRP5 polymorphisms and obesity, 27 single-nucleotide polymorphisms (SNPs), spacing about 5 kb apart on average and covering the full transcript length of the LRP5 gene, were genotyped in 1873 Caucasian people from 405 nuclear families. Obesity (defined as body mass index (BMI) >30 kg/m(2)) and three obesity-related phenotypes (BMI, fat mass and percentage of fat mass (PFM)) were investigated.

Results

Single markers (12 tagging SNPs and 4 untaggable SNPs) and haplotypes (5 blocks) were tested for

SUBMITTER: Guo YF 

PROVIDER: S-EPMC1829485 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature