Sequence features responsible for intron retention in human.

ABSTRACT:

Background

One of the least common types of alternative splicing is the complete retention of an intron in a mature transcript. Intron retention (IR) is believed to be the result of intron, rather than exon, definition associated with failure of the recognition of weak splice sites flanking short introns. Although studies on individual retained introns have been published, few systematic surveys of large amounts of data have been conducted on the mechanisms that lead to IR.

Results

TTo understand how sequence features are associated with or control IR, and to produce a generalized model that could reveal previously unknown signals that regulate this type of alternative splicing, we partitioned intron retention events observed in human cDNAs into two groups based on the relat

SUBMITTER: Sakabe NJ 

PROVIDER: S-EPMC1831480 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature