Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related death worldwide. Currently, tumor, node, metastasis (TNM) staging provides the most accurate prognostic parameter for patients with non-small cell lung cancer (NSCLC). However, the overall survival of patients with resectable tumors varies significantly, indicating the need for additional prognostic factors to better predict the outcome of the disease, particularly within a given TNM subset.

Methods and findings

In this study, we investigated whether adenocarcinomas and squamous cell carcinomas could be differentiated based on their global aberrant DNA methylation patterns. We performed restriction landmark genomic scanning on 40 patient samples and identified 47 DNA methylation targets that together could disting

SUBMITTER: Brena RM 

PROVIDER: S-EPMC1831740 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature