A comparative genomics approach to identifying the plasticity transcriptome.

ABSTRACT:

Background

Neuronal activity regulates gene expression to control learning and memory, homeostasis of neuronal function, and pathological disease states such as epilepsy. A great deal of experimental evidence supports the involvement of two particular transcription factors in shaping the genomic response to neuronal activity and mediating plasticity: CREB and zif268 (egr-1, krox24, NGFI-A). The gene targets of these two transcription factors are of considerable interest, since they may help develop hypotheses about how neural activity is coupled to changes in neural function.

Results

We have developed a computational approach for identifying binding sites for these transcription factors within the promoter regions of annotated genes in the mouse, rat, and human genomes. By c

SUBMITTER: Pfenning AR 

PROVIDER: S-EPMC1831778 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature