Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.

ABSTRACT:

Background

Allele frequencies reported from public databases or articles are mostly based on small sample sizes. Differences in genotype frequencies by age, race and sex have implications for studies designed to examine genetic susceptibility to disease. In a community-based cohort of 9,960 individuals, we compared the allele frequencies of 49 single nucleotide polymorphisms (SNPs) of genes involved in inflammatory pathways to the frequencies reported on public databases, and examined the genotypes frequencies by age and sex. The genes in which SNPs were analyzed include CCR2, CCR5, COX1, COX2, CRP, CSF1, CSF2, IFNG, IL1A, IL1B, IL2, IL4, IL6, IL8, IL10, IL13, IL18, LTA, MPO, NOS2A, NOS3, PPARD, PPARG, PPARGC1 and TNF.

Results

Mean(SD) age was 53.2(15.5); 98% were Caucasians

SUBMITTER: Huang HY 

PROVIDER: S-EPMC1838428 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature