Alteration in the gene expression pattern of primary monocytes after adhesion to endothelial cells.

ABSTRACT: Monocytes originate from precursors made in the bone and remain in the circulation for nearly 24 h. Much effort has been done to identify the molecules regulating transendothelial migration of monocytes during inflammatory conditions. In contrast, considerably less is known about the process of constitutive monocyte emigration although nearly 340 million monocytes leave the circulation each day in healthy individuals. Previous studies indicated that chemokines were up-regulated in monocytes cocultured with endothelial cells that induce the retraction of the latter cell type, thereby increasing vascular permeability. Thus, we hypothesized that the utilities required for efficient constitutive monocyte extravasation are generated by monocytes themselves because of adhesion to naïve endotheli

SUBMITTER: Thomas-Ecker S 

PROVIDER: S-EPMC1838499 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature