Expansion of the Bactericidal/Permeability Increasing-like (BPI-like) protein locus in cattle.

ABSTRACT:

Background

Cattle and other ruminants have evolved the ability to derive most of their metabolic energy requirement from otherwise indigestible plant matter through a symbiotic relationship with plant fibre degrading microbes within a specialised fermentation chamber, the rumen. The genetic changes underlying the evolution of the ruminant lifestyle are poorly understood. The BPI-like locus encodes several putative innate immune proteins, expressed predominantly in the oral cavity and airways, which are structurally related to Bactericidal/Permeability Increasing protein (BPI). We have previously reported the expression of variant BPI-like proteins in cattle (Biochim Biophys Acta 2002, 1579, 92-100). Characterisation of the BPI-like locus in cattle would lead to a better understandi

SUBMITTER: Wheeler TT 

PROVIDER: S-EPMC1839098 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature