Anticoagulation for three versus six months in patients with deep vein thrombosis or pulmonary embolism, or both: randomised trial.

ABSTRACT:

Objective

To determine the optimum duration of oral anticoagulant therapy after an episode of deep vein thrombosis or pulmonary embolism, or both.

Design

Multicentre, prospective, randomised study with follow-up for one year.

Setting

46 hospitals in United Kingdom.

Participants

Patients aged > or =18 with deep vein thrombosis or pulmonary embolism, or both.

Interventions

Three (n=369) or six months (n=380) of anticoagulation with heparin for five days accompanied and followed by warfarin, with a target international normalised ratio of 2.0-3.5.

Main outcome measures

Death from deep vein thrombosis or pulmonary embolism; failure to resolve, extension, recurrence of during treatment; recurrence after treatment; and major haemorrhage during treatment

SUBMITTER: Campbell IA 

PROVIDER: S-EPMC1839169 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature