Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis.

ABSTRACT:

Background

Lipids are an important and highly diverse class of molecules having structural, energy storage and signaling roles. Modern analytical technologies afford screening of many lipid molecular species in parallel. One of the biggest challenges of lipidomics is elucidation of important pathobiological phenomena from the integration of the large amounts of new data becoming available.

Results

We present computational and informatics approaches to study lipid molecular profiles in the context of known metabolic pathways and established pathophysiological responses, utilizing information obtained from modern analytical technologies. In order to facilitate identification of lipids, we compute the scaffold of theoretically possible lipids based on known lipid building block

SUBMITTER: Yetukuri L 

PROVIDER: S-EPMC1839890 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature