Gene expression signatures that predict radiation exposure in mice and humans.

ABSTRACT:

Background

The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure to ionizing radiation.

Methods and findings

We have made use of gene expression analysis of peripheral blood (PB) mononuclear cells to develop expression profiles that accurately reflect prior radiation exposure. We demonstrate that expression profiles can be developed that not only predict radiation exposure in mice but also distinguish the level of radiation exposure, ranging from 50 cGy to 1,000 cGy. Likewise, a molecular signature of radiation response developed solely from irradiated human patient samples can predict and distinguish irradiated huma

SUBMITTER: Dressman HK 

PROVIDER: S-EPMC1845155 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature