Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program.

ABSTRACT:

Background

Aging has been associated with widespread changes at the gene expression level in multiple mammalian tissues. We have used high density oligonucleotide arrays and novel statistical methods to identify specific transcriptional classes that may uncover biological processes that play a central role in mammalian aging.

Results

We identified 712 transcripts that are differentially expressed in young (5 month old) and old (25-month old) mouse skeletal muscle. Caloric restriction (CR) completely or partially reversed 87% of the changes in expression. Examination of individual genes revealed a transcriptional profile indicative of increased p53 activity in the older muscle. To determine whether the increase in p53 activity is associated with transcriptional activation of

SUBMITTER: Edwards MG 

PROVIDER: S-EPMC1847444 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature