Expression and function of TLR2, TLR4, and Nod2 in primary canine colonic epithelial cells.

ABSTRACT: The gut maintains a delicate balance between the downregulation of inflammatory reactions to commensal bacteria and the capacity to respond to pathogens with vigorous cellular and humoral immune responses. Intestinal epithelial cells, including colonic epithelial cells (CECs) possess many properties of cells of the innate immune system, in particular the ability to recognize and respond to microbial antigens. Recognition of microorganisms by CECs is based upon their recognition of signature molecules, called microbe-associated molecular patterns (MAMP), by pattern recognition receptors (PRR) including membrane toll-like receptors (TLR) and cytosolic Nod2, an intracellular counterpart of TLRs. The purpose of this study was to determine whether primary CECs from normal dogs express a functio

SUBMITTER: Swerdlow MP 

PROVIDER: S-EPMC1850225 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature