Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles.

ABSTRACT: Molecular classification of tumors based on their gene expression profiles promises to significantly refine diagnosis and management of cancer patients. The establishment of organ-specific gene expression patterns represents a crucial first step in the clinical application of the molecular approach. Here, we report on the gene expression profiles of 154 primary adenocarcinomas of the lung, colon, and ovary. Using high-density oligonucleotide arrays with 7129 gene probe sets, comprehensive gene expression profiles of 57 lung, 51 colon, and 46 ovary adenocarcinomas were generated and subjected to principle component analysis and to a cross-validated prediction analysis using nearest neighbor classification. These statistical analyses resulted in the classification of 152 of 154 of the adenoc

SUBMITTER: Giordano TJ 

PROVIDER: S-EPMC1850519 | biostudies-literature | 2001 Oct

REPOSITORIES: biostudies-literature