Faithful modeling of transient expression and its application to elucidating negative feedback regulation.

ABSTRACT: Modeling and analysis of genetic regulatory networks is essential both for better understanding their dynamic behavior and for elucidating and refining open issues. We hereby present a discrete computational model that effectively describes the transient and sequential expression of a network of genes in a representative developmental pathway. Our model system is a transcriptional cascade that includes positive and negative feedback loops directing the initiation and progression through meiosis in budding yeast. The computational model allows qualitative analysis of the transcription of early meiosis-specific genes, specifically, Ime2 and their master activator, Ime1. The simulations demonstrate a robust transcriptional behavior with respect to the initial levels of Ime1 and Ime2. The comp

SUBMITTER: Rubinstein A 

PROVIDER: S-EPMC1851052 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature