Combinatorial transcriptional control of the lactose operon of Escherichia coli.

ABSTRACT: The goal of systems biology is to understand the behavior of the whole in terms of knowledge of the parts. This is hard to achieve in many cases due to the difficulty of characterizing the many constituents involved in a biological system and their complex web of interactions. The lac promoter of Escherichia coli offers the possibility of confronting "system-level" properties of transcriptional regulation with the known biochemistry of the molecular constituents and their mutual interactions. Such confrontations can reveal previously unknown constituents and interactions, as well as offer insight into how the components work together as a whole. Here we study the combinatorial control of the lac promoter by the regulators Lac repressor (LacR) and cAMP-receptor protein (CRP). A previous in

SUBMITTER: Kuhlman T 

PROVIDER: S-EPMC1851613 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature