Ontology highlight
ABSTRACT:
SUBMITTER: Saez-Cirion A
PROVIDER: S-EPMC1851664 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Sáez-Cirión Asier A Lacabaratz Christine C Lambotte Olivier O Versmisse Pierre P Urrutia Alejandra A Boufassa Faroudy F Barré-Sinoussi Françoise F Delfraissy Jean-François JF Sinet Martine M Pancino Gianfranco G Venet Alain A
Proceedings of the National Academy of Sciences of the United States of America 20070411 16
Some rare HIV-1-infected individuals, referred to as HIV controllers (HIC), have persistently undetectable plasma viral load in the absence of therapy. This control of HIV-1 replication has been associated with a strong, multifunctional specific CD8(+) T cell response. However, no direct link between this immune response and the control of viremia has so far been provided. We investigated parameters of specific CD8(+) T cell response and in vitro susceptibility to HIV-1 infection in 11 HIC. We f ...[more]