Intermittent intravaginal antibiotic treatment of bacterial vaginosis in HIV-uninfected and -infected women: a randomized clinical trial.

ABSTRACT:

Objective

Assess efficacy of intermittent intravaginal metronidazole gel treatment in reducing frequency of bacterial vaginosis (BV).

Design

Randomized, double-masked, placebo-controlled phase 3 trial.

Setting

Postnatal and family planning clinics of the Queen Elizabeth Central Hospital and two health centers in Blantyre, Malawi.

Participants

Nonpregnant HIV-uninfected and -infected women.

Intervention

Intravaginal metronidazole treatment and placebo gels provided at baseline and every 3 mo for 1 y.

Outcome measures

PRIMARY: Cross-sectional and longitudinal comparisons of BV frequency at baseline, 1 mo after product dispensation (post-treatment evaluation [PTE]), and every quarterly visit. Secondary: Effect of treatment on BV clearance and recurre

SUBMITTER: Taha TE 

PROVIDER: S-EPMC1851729 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature