Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling.

ABSTRACT:

Background

The heart forms from a linear tube that is subject to complex remodeling during embryonic development. Hallmarks of this remodeling are the looping of the heart tube and the regionalization into chamber and non-chamber myocardium. Cardiomyocytes in the future chamber myocardium acquire different cellular and physiological characteristics through activation of a chamber-specific genetic program, which is in part mediated by T-box genes.

Methodology/principal finding

We characterize two new zebrafish T-box transcription factors, tbx3b and tbx2a, and analyze their role during the development of the atrioventricular canal. Loss- and gain-of-function analyses demonstrate that tbx3b and tbx2a are necessary to repress the chamber-genetic program in the non-chamber myocar

SUBMITTER: Ribeiro I 

PROVIDER: S-EPMC1851989 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature