Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner.

ABSTRACT: Inhibition of osteoclast (OC) activity has been associated with decreased tumor growth in bone in animal models. Increased recognition of factors that promote osteoclastic bone resorption in cancer patients led us to investigate whether increased OC activation could enhance tumor growth in bone. Granulocyte colony-stimulating factor (G-CSF) is used to treat chemotherapy-induced neutropenia, but is also associated with increased markers of OC activity and decreased bone mineral density (BMD). We used G-CSF as a tool to investigate the impact of increased OC activity on tumor growth in 2 murine osteolytic tumor models. An 8-day course of G-CSF alone (without chemotherapy) significantly decreased BMD and increased OC perimeter along bone in mice. Mice administered G-CSF alone demonstrated sig

SUBMITTER: Hirbe AC 

PROVIDER: S-EPMC1852257 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature