Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction.

ABSTRACT: Our goal in the current report was to design a new functional magnetic resonance imaging (fMRI) task to probe the role of the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) in processing of salient symptom-related cues during the simultaneous performance of an unrelated task in drug-addicted persons. We used a novel fMRI color-word drug Stroop task in 14 individuals with cocaine use disorders; subjects had to press for color of drug vs. matched neutral words. Although there were no accuracy or speed differences between the drug and neutral conditions in the current sample of subjects, drug words were more negatively valenced than the matched neutral words. Further, consistent with prior reports in individuals with other psychopathologies using different Stroop fMRI paradigm

SUBMITTER: Goldstein RZ 

PROVIDER: S-EPMC1852512 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature