Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes.

ABSTRACT:

Background

Transposons, i.e. transposable elements (TEs), are the major internal spontaneous mutation agents for the variability of eukaryotic genomes. To address the general issue of whether transposons mediate genomic changes in environment-adaptation genes, we scanned two alleles per each of the six xenobiotic-metabolizing Helicoverpa zea cytochrome P450 loci, including CYP6B8, CYP6B27, CYP321A1, CYP321A2, CYP9A12v3 and CYP9A14, for the presence of transposon insertions by genome walking and sequence analysis. We also scanned thirteen Drosophila melanogaster P450s genes for TE insertions by in silico mapping and literature search.

Results

Twelve novel transposons, including LINEs (long interspersed nuclear elements), SINEs (short interspersed nuclear elements), MITEs (min

SUBMITTER: Chen S 

PROVIDER: S-EPMC1852546 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature