Improving power in contrasting linkage-disequilibrium patterns between cases and controls.

ABSTRACT: Genetic association studies offer an opportunity to find genetic variants underlying complex human diseases. The success of this approach depends on the linkage disequilibrium (LD) between markers and the disease variant(s) in a local region of the genome. Because, in the region with a disease mutation, the LD pattern among markers may differ between cases and controls, in some scenarios, it is useful to compare a measure of this LD, to map disease mutations. For example, using the composite correlation to characterize the LD among markers, Zaykin et al. recently suggested an "LD contrast" test and showed that it has high power under certain haplotype-driven disease models. Furthermore, it is likely that individual variants observed at different positions in a gene act jointly with each ot

SUBMITTER: Wang T 

PROVIDER: S-EPMC1852728 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature