Complex regulation and multiple developmental functions of misfire, the Drosophila melanogaster ferlin gene.

ABSTRACT:

Background

Ferlins are membrane proteins with multiple C2 domains and proposed functions in Ca2+ mediated membrane-membrane interactions in animals. Caenorhabditis elegans has two ferlin genes, one of which is required for sperm function. Mammals have several ferlin genes and mutations in the human dysferlin (DYSF) and otoferlin (OTOF) genes result in muscular dystrophy and hearing loss, respectively. Drosophila melanogaster has a single ferlin gene called misfire (mfr). A previous study showed that a mfr mutation caused male sterility because of defects in fertilization. Here we analyze the expression and structure of the mfr gene and the consequences of multiple mutations to better understand the developmental function of ferlins.

Results

We show that mfr is expressed in t

SUBMITTER: Smith MK 

PROVIDER: S-EPMC1853072 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature