Gene expression profiles in rat brain disclose CNS signature genes and regional patterns of functional specialisation.

ABSTRACT:

Background

The mammalian brain is divided into distinct regions with structural and neurophysiological differences. As a result, gene expression is likely to vary between regions in relation to their cellular composition and neuronal function. In order to improve our knowledge and understanding of regional patterns of gene expression in the CNS, we have generated a global map of gene expression in selected regions of the adult rat brain (frontomedial-, temporal- and occipital cortex, hippocampus, striatum and cerebellum; both right and left sides) as well as in three major non-neural tissues (spleen, liver and kidney) using the Applied Biosystems Rat Genome Survey Microarray.

Results

By unsupervised hierarchical clustering, we found that the transcriptome within a region was

SUBMITTER: Stansberg C 

PROVIDER: S-EPMC1853090 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature