Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation.

ABSTRACT:

Background

In general, inflammation plays a role in most bladder pathologies and represents a defense reaction to injury that often times is two edged. In particular, bladder neurogenic inflammation involves the participation of mast cells and sensory nerves. Increased mast cell numbers and tryptase release represent one of the prevalent etiologic theories for interstitial cystitis and other urinary bladder inflammatory conditions. The activity of mast cell-derived tryptase as well as thrombin is significantly increased during inflammation. Those enzymes activate specific G-protein coupled proteinase-activated receptors (PAR)s. Four PARs have been cloned so far, and not only are all four receptors highly expressed in different cell types of the mouse urinary bladder, but their expr

SUBMITTER: Saban R 

PROVIDER: S-EPMC1853108 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature