Personality traits of agreeableness and extraversion are associated with ADH4 variation.

ABSTRACT:

Background

Personality traits are associated with substance dependence (SD); genetic factors may influence both. Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study.

Methods

We assessed dimensions of the five-factor model of personality in 243 subjects with SD (175 European Americans [EAs] and 68 African Americans [AAs]) and 296 healthy control subjects (256 EAs and 40 AAs). We also genotyped 7 ADH4 markers (spanning the locus) and 38 unlinked ancestry-informative markers in these subjects. The relationships between the diplotypes, alleles, and genotypes at ADH4 and personality traits were examined using multivariate analysis of covariance (MANCOVA),

SUBMITTER: Luo X 

PROVIDER: S-EPMC1853245 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature