P-selectin activates integrin-mediated colon carcinoma cell adhesion to fibronectin.

ABSTRACT: During hematogenous cancer metastasis, tumor cells separate from a primary mass, enter the bloodstream, disperse throughout the body, migrate across vessel walls, and generate distant colonies. The later steps of metastasis superficially resemble leukocyte extravasation, a process initiated by selectin-mediated cell tethering to the blood vessel wall followed by integrin-mediated arrest and transendothelial migration. Some cancer cells express P-selectin ligands and attach to immobilized P-selectin, suggesting that these cells can arrest in blood vessels using sequential selectin- and integrin-mediated adhesion, as do leukocytes. We hypothesize that selectin binding may regulate subsequent integrin-mediated steps in metastasis. Using a model system of cultured Colo 320 human colon adenocar

SUBMITTER: Reyes-Reyes ME 

PROVIDER: S-EPMC1853301 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature