Ontology highlight
ABSTRACT:
SUBMITTER: Sullivan KM
PROVIDER: S-EPMC18538 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
Sullivan K M KM Scott K K Zuker C S CS Rubin G M GM
Proceedings of the National Academy of Sciences of the United States of America 20000501 11
We have investigated the role of the ryanodine receptor in Drosophila development by using pharmacological and genetic approaches. We identified a P element insertion in the Drosophila ryanodine receptor gene, Ryanodine receptor 44F (Ryr), and used it to generate the hypomorphic allele Ryr(16). An examination of hypodermal, visceral, and circulatory muscle showed that, in each case, muscle contraction was impaired in Ryr(16) larvae. Treatment with the drug ryanodine, a highly specific modulator ...[more]