The disarrayed mutation results in cell cycle and neurogenesis defects during retinal development in zebrafish.

ABSTRACT:

Background

The vertebrate retina is derived from proliferative neuroepithelial cells of the optic cup. During retinal development, cell proliferation and the processes of cell cycle exit and neurogenesis are coordinated in neuroepithelial progenitor cells. Previous studies have demonstrated reciprocal influences between the cell cycle and neurogenesis. However the specific mechanisms and exact relationships of cell cycle regulation and neurogenesis in the vertebrate retina remain largely unknown.

Results

We have isolated and characterized a zebrafish mutant, disarrayed (drya64), which exhibits retinal defects in cell cycle regulation and neurogenesis. By 42 hours post fertilization, disarrayed mutants show small eyes and a reduced forebrain. Other aspects of development appe

SUBMITTER: Baye LM 

PROVIDER: S-EPMC1854893 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature