Loss of fibulin-2 expression is associated with breast cancer progression.
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ABSTRACT:
SUBMITTER: Yi CH
PROVIDER: S-EPMC1854949 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Publications
Loss of fibulin-2 expression is associated with breast cancer progression.
Yi Chun-Hui CH Smith David J DJ West William W WW Hollingsworth Michael A MA
The American journal of pathology 20070501 5
Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines. Fibulin-2 protein expression was also decreased in breast cancer tissue samples as evaluated by immunohistochemistry. Reintroduction of Fibulin-2 into breast cancer cell lines that do not express Fibulin-2 reduced cancer cell motility and invasion in vitro but had no effect on cell growth and adhesion properties. Together with evidence that Fibulin-2 contr ...[more]
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