Tandem gene arrays in Trypanosoma brucei: comparative phylogenomic analysis of duplicate sequence variation.

ABSTRACT:

Background

The genome sequence of the protistan parasite Trypanosoma brucei contains many tandem gene arrays. Gene duplicates are created through tandem duplication and are expressed through polycistronic transcription, suggesting that the primary purpose of long, tandem arrays is to increase gene dosage in an environment where individual gene promoters are absent. This report presents the first account of the tandem gene arrays in the T. brucei genome, employing several related genome sequences to establish how variation is created and removed.

Results

A systematic survey of tandem gene arrays showed that substantial sequence variation existed across the genome; variation from different regions of an array often produced inconsistent phylogenetic affinities. Phylogenetic re

SUBMITTER: Jackson AP 

PROVIDER: S-EPMC1855330 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature