Evaluation of genetic factors for warfarin dose prediction.

ABSTRACT:

Objectives

Warfarin is a commonly prescribed anticoagulant drug used to prevent thromboses that may arise as a consequence of orthopedic and vascular surgery or underlying cardiovascular disease. Warfarin is associated with a notoriously narrow therapeutic window where small variations in dosing may result in hemorrhagic or thrombotic complications. To ultimately improve dosing of warfarin, we evaluated models for stable maintenance dose that incorporated both clinical and genetic factors.

Method

A model was constructed by evaluating the contribution to dosing variability of the following clinical factors: age, gender, body surface area, and presence or absence of prosthetic heart valves or diabetes. The model was then sequentially expanded by incorporating polymorphisms of

SUBMITTER: Caldwell MD 

PROVIDER: S-EPMC1855340 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature