Intravesicular and intervesicular interaction by orthogonal multivalent host-guest and metal-ligand complexation.

ABSTRACT: Host vesicles composed of amphiphilic beta-cyclodextrin CD1 recognize metal-coordination complexes of the adamantyl-functionalized ethylenediamine ligand L via hydrophobic inclusion in the beta-cyclodextrin cavities at the vesicle surface. In the case of Cu(II) and L, the resulting coordination complex was exclusively CuL(2), and the interaction with the host vesicles was intravesicular, unless the concentration of metal complex and vesicles was high (>0.1 mM). In the case of Ni(II) and L, a mixture was formed consisting of mainly NiL and NiL(2), the interaction with the host vesicles was effectively intervesicular, and addition of the guest-metal complex resulted in aggregation of the vesicles into dense, multilamellar clusters even in dilute solution [1 microM Ni(II)]. The metal-L comple

SUBMITTER: Lim CW 

PROVIDER: S-EPMC1855387 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature