GABAergic inhibition at dendrodendritic synapses tunes gamma oscillations in the olfactory bulb.

ABSTRACT: In the olfactory bulb (OB), odorants induce oscillations in the gamma range (20-80 Hz) that play an important role in the processing of sensory information. Synaptic transmission between dendrites is a major contributor to this processing. Glutamate released from mitral cell dendrites excites the dendrites of granule cells, which in turn mediate GABAergic inhibition back onto mitral cells. Although this reciprocal synapse is thought to be a key element supporting oscillatory activity, the mechanisms by which dendrodendritic inhibition induces and maintains gamma oscillations remain unknown. Here, we assessed the role of the dendrodendritic inhibition, using mice lacking the GABA(A) receptor alpha1-subunit, which is specifically expressed in mitral cells but not in granule cells. The sponta

SUBMITTER: Lagier S 

PROVIDER: S-EPMC1855399 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature