Negative regulation of Bacillus anthracis sporulation by the Spo0E family of phosphatases.

ABSTRACT: The initiation of sporulation in Bacillus species is controlled by the phosphorelay signal transduction system. Multiple regulatory elements act on the phosphorelay to modulate the level of protein phosphorylation in response to cellular, environmental, and metabolic signals. In Bacillus anthracis nine possible histidine sensor kinases can positively activate the system, while two response regulator aspartyl phosphate phosphatases of the Rap family negatively impact the pathway by dephosphorylating the Spo0F intermediate response regulator. In this study, we have characterized the B. anthracis members of the Spo0E family of phosphatases that specifically dephosphorylate the Spo0A response regulator of the phosphorelay and master regulator of sporulation. The products of four genes were abl

SUBMITTER: Bongiorni C 

PROVIDER: S-EPMC1855805 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature