The redox regulator Fnr is required for fermentative growth and enterotoxin synthesis in Bacillus cereus F4430/73.

ABSTRACT: Glucose-grown cells of Bacillus cereus respond to anaerobiosis and low extracellular oxidoreduction potentials (ORP), notably by enhancing enterotoxin production. This response involves the ResDE two-component system. We searched the B. cereus genome for other redox response regulators potentially involved in this adaptive process, and we identified one gene encoding a protein predicted to have an amino acid sequence 58% identical (80% similar) to that of the Bacillus subtilis Fnr redox regulator. The fnr gene of the food-borne pathogen B. cereus F4430/73 has been cloned and partially characterized. We showed that fnr was up-regulated during anaerobic fermentation, especially when fermentation occurred at low ORP (under highly reducing conditions). The expression of fnr was down-regulated

SUBMITTER: Zigha A 

PROVIDER: S-EPMC1855811 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature