Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study.

ABSTRACT:

Background

The sex hormone-binding globulin (SHBG) is a carrier protein that modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer. We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of epithelial ovarian cancer.

Methods

The study population included 264 women with ovarian carcinoma and 625 controls participating in a population-based case-control study in Poland. Five common single nucleotide polymorphisms (SNPs) in SHGB and five in ATP1B2 were selected to capture most common variation in this region.

Results

None of the SNPs evaluated was significantly associated with ovarian cancer risk, including the putative functional SNPs SHBG D3

SUBMITTER: Garcia-Closas M 

PROVIDER: S-EPMC1855931 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature