Role of the MHC2TA gene in autoimmune diseases.

ABSTRACT:

Objectives

Expression of major histocompatibility complex (MHC) class II genes is almost exclusively regulated by the class II transactivator. A promoter polymorphism (-168A/G, rs3087456) in the MHC2TA gene was associated with increased susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction in a northern European population. However, no evidence of association of this MHC2TA variant with the two autoimmune diseases could be subsequently detected in independent cohorts.

Aim

To test the aforementioned single nucleotide polymorphism and another G-->C change (nt1614 from coding sequence, rs4774) to analyse the haplotype pattern in this MHC2TA gene.

Methods

A case-control study was performed with 350 patients with rheumatoid arthritis, 396 pat

SUBMITTER: Martinez A 

PROVIDER: S-EPMC1855999 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature