Influence of ghrelin on interdigestive gastrointestinal motility in humans.

ABSTRACT:

Background

Recent studies in animals have shown that ghrelin stimulates upper gastrointestinal motility through the vagus and enteric nervous system. The aim of the present study therefore was to simultaneously investigate the effect of administration of ghrelin on upper gastrointestinal motility and to elucidate its mode of action by measuring plasma levels of gastrointestinal hormones in humans.

Materials and methods

Nine healthy volunteers (four males; aged 22-35 years) underwent combined antroduodenal manometry and proximal stomach barostat study on two separate occasions at least one week apart. Twenty minutes after the occurrence of phase III of the migrating motor complex (MMC), saline or ghrelin 40 mug was administered intravenously over 30 minutes in a double blind,

SUBMITTER: Tack J 

PROVIDER: S-EPMC1856079 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature