Prediction of liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfected patients by simple non-invasive indexes.

ABSTRACT:

Background

Liver biopsy is an invasive technique with associated major complications. There is no information on the validity of five non-invasive indexes based on routinely available parameters, estimated and validated in hepatitis C virus (HCV) monoinfected patients, in human immunodeficiency virus (HIV)/HCV coinfected patients.

Aim

To validate these predictive models of liver fibrosis in HIV/HCV coinfected patients.

Patients

A total of 357 (90%) of 398 patients from five hospitals were investigated, who underwent liver biopsy and who had complete data to validate all of the models considered.

Methods

The predictive accuracy of the indexes was tested by measuring areas under the receiver operating characteristic curves. Diagnostic accuracy was calculated by e

SUBMITTER: Macias J 

PROVIDER: S-EPMC1856097 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature